Thealoz Duo Eye Drops - Rapid & Long-Lasting Relief for Dry, Tired & Sore Eyes | Gentle, Preservative-Free Formula | Suitable for Contact Lens Wearers | 10 ml (300 Drops)

Product Information

Trehalose-containing eyedrops have previously been shown to be effective in in vitro, 9, 10 ex vivo, 11 and in vivo animal studies 12 as well as in a few clinical studies. 13– 15 A further advantage of this formulation is a longer residency time than hyaluronate alone, as recently shown in a randomized, double-masked study. 16 Clinical studies have investigated the use of trehalose in eyedrops with positive results. These larger studies established significant benefits of trehalose-containing eyedrops over saline and hydroxymethylcellulose eyedrops. 13, 14 The utility of hyaluronate-containing eyedrops is well established in the treatment of dry eye. 17– 22 Dry Eye means that your eyes may not be making enough tears, the tears you are making are of poor quality or evaporate faster than they should. Dry eye is a condition where the surface of the eye becomes inflamed and sore due to a poor relationship between the tear film and the eyelids. This might be because your eyes are not producing enough tears, or that the chemistry of the tear film is out of balance. The liquid gel drops come in easy to squeeze single dose vial, A drop can be applied as often as necessary throughout the day The primary endpoint was analyzed using a mixed-effects analysis of covariance, considering the patient within the sequence as a random effect and using the type III Sum of Squares for evaluation of the effect.

Palpebral signs including meibomitis and other blepharitis, conjunctival discharge, chemosis, folliculo-papillary conjunctivitis, filamentary keratitis, and other relevant ocular signs were evaluated in each eye at days 0, 7, 12, and 19. Palpebral signs were evaluated on a four-point scale (0= none, 1= mild, 2= moderate, 3= severe). Trehalose protects the epithelial cells on the ocular surface, improving their resistance to daily stress of dry environments and tear film changes in a dry eye; it has very high water retention capabilities with both bioprotection 1,2 and osmoprotection properties 2-7Thealoz Duo ® (Laboratoires Théa, Clermont Ferrand, France) is an artificial tear preparation containing two active ingredients: trehalose, a naturally occurring disaccharide of glucose that appears to function in an anhydrobiotic capacity in many organisms, and hyaluronate, a widely distributed anionic glycosaminoglycan polysaccharide with biological roles associated with its lubricative and water-retaining properties. Trehalose has been shown not only to stabilize both bilipid membranes and labile proteins against desiccation, but also to have a protective effect against desiccation and oxidative insult in the mammalian eye. 4 Hyaluronate is a component of many medicinal preparations including those used in cataract surgery, for the treatment of dry eye as well as many commercial skin preparations and antiaging creams. 5 It is also present in natural human tears. 6 Patients were randomized to Thealoz Duo ® or Systane ®. Both treatments were administered as one drop five times daily in both eyes for 7 days followed by a washout period of 5 days, whereupon patients switched to the alternate treatment for 5 days. The two treatments were presented in different 10 mL bottles. As the bottle design is an integral part of the product conventional treatment, blinding was not possible. The study was a single center randomized, open label, crossover trial. Thealoz Duo ® was compared with an active control Systane ®, an established and effective treatment in dry eye. Clinically proven to stabilize tear film, reduce inflammatory markers and restore normal osmotic balance. A global ocular staining score was determined from the Oxford 0–5 grading scheme that assesses global ocular staining in corneal area from fluorescein coloration and in temporal and nasal areas from lissamine green coloration in both eyes. Ocular staining was measured during visits at days 0, 7, 12, and 19.

Other efficacy analyses are presented as descriptive statistics for baseline, under treatment, and change from baseline (when applicable). Comparison between treatments was performed for quantitative criteria using Student’s t-test for paired samples or a Wilcoxon signed-rank test. A P-value less than 0.05 was considered statistically significant. We recommend you apply 1 drop to each eye from 4 to 6 times daily, however this can increase or decrease without any cause for concern, dependant on the severity of your symptoms No meibomitis or other blepharitis, conjunctival discharge, folliculo-papillary conjunctivitis or filamentary keratitis was reported at baseline or during either treatment.Oxford fluorescein staining scores at baseline and during treatment baseline and after 7 days’ treatment with Thealoz Duo ® or Systane ®. The Schirmer test was performed, without anesthesia, in each eye at visits on days 0, 7, 12, and 19. contains 30 single-use unit doses. Once the vial has been opened throw away, even if there is a small amount left, do not reuse. Once opened the microbial protection of the solution cannot be guaranteed.